226
CYDiagnosed as a lung adenocarcinoma, signet-ring cell type.
#pathology #cytology #lungcancer #adenocarcinoma #signetring
an extremely rare, aggressive, and often poor-prognosis subtype of lung adenocarcinoma
@cytologistfindscells
#Smallcell
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SHCancer cells are constantly growing and dying. When they break down, they can release small fragments of their DNA into the bloodstream. These fragments are called circulating tumor DNA, or ctDNA.
New blood tests can detect these fragments using highly sensitive sequencing technologies. Because the DNA comes directly from tumor cells, ctDNA can sometimes reveal whether cancer is still present in the body even when scans appear normal.
In colorectal cancer, ctDNA is being actively studied to help detect minimal residual disease after surgery, monitor treatment response, and identify recurrence earlier.
But there’s an important caveat.
Not all tumors shed detectable DNA into the bloodstream. Some cancers release very little ctDNA, especially when the tumor burden is small or when metastases are confined to certain locations. That means a negative ctDNA test does not always guarantee that cancer is absent.
For that reason, ctDNA is best understood as one tool among many. It complements imaging, pathology, and clinical follow-up rather than replacing them.
This is a rapidly evolving area of cancer research, and we’re still learning how best to use ctDNA to guide treatment decisions.
Colorectal Cancer, Explained. Day 11 ✅
@shrutipatelmd
6.7K
MU“Carcinoma Under the Lens: When Cells Lose Their Discipline”
🔬 Cytology Report :
Cohesive clusters & sheets of epithelial cells : strong epithelial origin
Marked anisocytosis & anisokaryosis : clear cellular pleomorphism
High nuclear-to-cytoplasmic (N:C) ratio in multiple cells
Round to oval nuclei with:
Coarse, irregular chromatin
Prominent nucleoli
Cell crowding & overlapping : loss of normal architecture
Basophilic cytoplasm, moderately abundant
Poorly defined borders in some cells
Background shows erythrocytes with minimal inflammation (Neutrophils) .
Key Malignant Features Observed:
1) Nuclear pleomorphism
2) Prominent nucleoli
3) High N:C ratio
4) Cellular disorganization
5) Loss of polarity
6) Cohesive epithelial behavior
@mustafa_elsobky
1.1K
PASmall cells. Big implications. 🫁
Yesterday’s diagnosis: Small Cell Lung Carcinoma.
This "small" tumor carries a big punch. When you see this on a slide, look for these 4 classic features:
•Nuclear Molding: Nuclei pressing against each other like a puzzle.
•Salt & Pepper Chromatin: That characteristic finely granular look.
•Azzopardi Effect: DNA from necrotic cells staining the vessel walls.
IHC Profile: Positive for Synaptophysin, Chromogranin, and CD56. Don't forget that Ki-67 is usually >90%!
#pathology #lungpathology #sclc #histopathology #panorama
@panorama_pathologica
6.6K
MUThe main Carcinoma features visible here are:
1) Cohesive epithelial clustering rather than discrete round cells
2) Polygonal cells with distinct borders
3) Anisocytosis and anisokaryosis
4) Prominent nucleoli : multiple in some cells
5) Nuclear crowding / overlapping
6) High N:C variation in some cells
7) Possible acinar/glandular tendency in part of the cluster
8) Mild cytoplasmic vacuolation
@mustafa_elsobky
1.8K
SCDoing a lot of genome 🧬 editing lately to understand how different genes affect leukemia development.
See an example of CRISPR/Cas9 use for oncoprotein live visualization in cancer cells in our latest CELL paper.
@sciencyelmira
90
SUHallmarks of cancer #surgerymuchattlu #surgerytalkz #surgeryresidency
@surgery_talkz
9.3K
SCUsing CRISPR-Cas9 system almost every day to understand how leukemia develops.
The Nobel Prize in 2020 (shared by Jennifer Doudna and Emmanuelle Charpentier) was just the beginning. Now CRISPR-Cas9 technology is everywhere.
In CANCER research, we use it for:
❌Gene Knockout: Deleting genes to see if cancer survives without them.
✍🏼Gene Correction: fixing the mutations in the oncogenes.
💡Protein Tagging: Adding 'fluorophores” to the proteins so we can watch them move in live cells.
🔬Live Imaging: Using dCas9 as a GPS to find and watch specific genetic loci inside the live cells.
You can read our recent Cell paper to learn how we used CRISPR-Cas9 system to visualize one of the most common oncogene in leukemia- NPM1, in live cells, and proved that it phase-separates and forms nuclear condensates.
Do you use CRISPR-Cas9 in your work?
@sciencyelmira
1.8K
DEWhen cells are dividing even when they aren’t supposed to, this can result in cancer - a group of diseases characterized by uncontrolled cell growth. Cancer is caused by a series of mutations that prevents the proper functioning of the cell cycle checkpoints (and up to 30% of human cancers have mutations in the Ras signaling pathway).
Normally, cells experience something known as density-dependent inhibition. Via juxtracrine signaling, cells will signal each other not to divide. The cell cycle will stop once a certain density is reached. Cancer cells have mutations allowing them to ignore this, resulting in the formation of tumors.
Also mediated through juxtracrine signaling, many cell types must be in contact with a solid surface (typically another layer of cells) in order to divide. This is known as anchorage-dependent inhibition. When anchorage-dependent cells detach from the surrounding extracellular matrix, they undergo a type of programmed cell death known as anoikis. When cancer cells become anchorage-independent, metastasis - the spreading of cells from a tumor to another area of the body - becomes possible.
#study #apbio #biology #apbiology #apbioreview
@delmos.world
1.2K
PAUnderstanding what a➖NEGATIVE #ctDNA 🩸🧬 liquid biopsy test result may mean in someone with #cancer.
@pashtoonkasi
127
MEVIsit
https://sidibooks.ca/ https://www.youtube.com/@medicinein3minutes519https:
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Adenocarcinoma: peripheral, common in women, no smoking link. Not a paraneoplastic syndrome. #MedicalFacts #HealthEducation #CancerAwareness #Adenocarcinoma #MedicalReels #HealthTips #LearnOnReels
@medicine3minutes
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