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#Davidsinclair Reel by @neuros_europe - 🔝 Peste 25 de ani de cercetare în longevitate. O singură misiune: o viață mai lungă și mai sănătoasă pentru fiecare dintre noi. ‼️ Pe 20 iunie, la Br
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@neuros_europe
🔝 Peste 25 de ani de cercetare în longevitate. O singură misiune: o viață mai lungă și mai sănătoasă pentru fiecare dintre noi. ‼️ Pe 20 iunie, la Brain Event 2026, în București, David Sinclair, cercetător la Harvard, vorbește despre ce știm astăzi, pe bază de știință, despre încetinirea îmbătrânirii și optimizarea sănătății pe termen lung. 📍 20 iunie 2026, București 📅 https://brain-event.com/ #brainevent #davidsinclair #davidsinclairphd #longevitate #clinicaneuros
#Davidsinclair Reel by @thediaryofaceopodcast (verified account) - This is what ageing feels like... Comment 'watch' and I'll personally DM you this conversation. David Sinclair describes how ageing affects the body
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@thediaryofaceopodcast
This is what ageing feels like... Comment ‘watch’ and I’ll personally DM you this conversation. David Sinclair describes how ageing affects the body, from weakness and pain to reduced vision and hearing. He explains that simulations using weighted suits and sensory limitations can help younger people understand these changes, often revealing how physically and mentally challenging later life can become. What would you change now to protect your future health? Credit: @davidsinclairphd x @thediaryofaceopodcast
#Davidsinclair Reel by @tejard (verified account) - REVERTER O ENVELHECIMENTO: será possível ? Nos laboratórios de Boston, nos Estados Unidos, ratos velhos e cegos recuperaram a visão e desenvolveram c
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@tejard
REVERTER O ENVELHECIMENTO: será possível ? Nos laboratórios de Boston, nos Estados Unidos, ratos velhos e cegos recuperaram a visão e desenvolveram cérebros mais jovens e inteligentes, além de músculos e tecidos renais mais saudáveis. Por outro lado, camundongos jovens envelheceram prematuramente, com resultados devastadores para quase todos os tecidos de seus corpos. Os experimentos mostram que o envelhecimento é um processo reversível, capaz de ser conduzido “para frente e para trás à vontade”, disse o especialista em antienvelhecimento David Sinclair, professor de genética no Blavatnik Institute da Harvard Medical School e co-diretor do Paul F. Glenn Center, para a pesquisa em biologia do envelhecimento. De acordo com ele nossos corpos possuem uma cópia de ‘backup’ de nossa juventude que pode ser acionada para se regenerar. Os experimentos combinados, publicados pela primeira vez na revista Cell, desafiam a crença científica de que o envelhecimento é resultado de mutações genéticas que prejudicam nosso DNA, criando um ferro-velho de tecido celular danificado que pode levar à deterioração, doenças e morte. Acreditam que seja uma perda de informação que leve ao envelhecimento –uma perda na capacidade da célula de ler seu DNA original, de modo que ela se esqueça de como funcionar –da mesma forma que um computador antigo pode desenvolver um software corrompido, que chamam de teoria da informação do envelhecimento. #jamartejada #farmaceutico #envelhecimento #ciencia #healthylifestyle #pharmacy #old #age
#Davidsinclair Reel by @pure.nmn - @davidsinclairphd yesterday on @thediaryofaceopodcast Talking about the benefits of NMN. Dr David Sinclair advises taking a gram of NMN doubles the
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@pure.nmn
@davidsinclairphd yesterday on @thediaryofaceopodcast Talking about the benefits of NMN. Dr David Sinclair advises taking a gram of NMN doubles the bodies NAD+ levels, lowering body weight, helping inflammation and changing cholesterol levels in a positive way. Dr David Sinclair and his father have been taking NMN for over a decade now. #nmn #davidsinclair #longevity #stevenbartlett
#Davidsinclair Reel by @bilimcepte - Harvard Tıp Fakültesi'nde moleküler biyoloji alanında çalışan David Sinclair, yaşlanma ve epigenetik üzerine çalışmalarıyla ünlü bir biyolog. Yaşlanma
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@bilimcepte
Harvard Tıp Fakültesi'nde moleküler biyoloji alanında çalışan David Sinclair, yaşlanma ve epigenetik üzerine çalışmalarıyla ünlü bir biyolog. Yaşlanmayı geri çevirebilme odaklı deneylerde bulunuyor ve bulduğu sonuçlar gerçekten devrim niteliğinde. Ed Mylett’e konuk olduğu bu programda, bu konuyla alakalı şaşırtıcı bilgiler sunuyor... Ne dersiniz, sizce anlattığı şeylerin gerçekleştiğine şahit olur muyuz? ( 📹: @edmylett @davidsinclairphd ) @basari.okulu Farelerde yaşlanma sürecini geri çevirmeyi başaran Harvardlı bilim insanı David Sinclair, "Çoğumuz ölmeden önce bunun insanlara uygulanacağını göreceğiz" Sinclair ve ekibi 2020'de yayımladığı çalışmada, erişkin hücreleri kök hücrelere çeviren proteinleri kullanarak farelerde yaşlanan hücreleri gençleştirmeyi başarmıştı. Araştırmada, görme yetisi zayıflamış ve retinaları hasar almış yaşlı bir farenin, bu işlem sonunda en az yavruları kadar iyi görmeye başladığı ortaya çıkmıştı. Son 20 yıldır yaşlanmayı geciktirme ve tersine çevirme üzerine araştırmalar yapan Sinclair, çalışmanın umut vaat ettiğini söyllüyor, "Anlayabildiğimiz kadarıyla bu kalıcı bir dönüşüm. Bunun, yaşlanmanın geri çevrilmesi için vücudun her yerinde uygulanabilecek evrensel bir süreç olabileceğini düşünüyoruz" diyor
#Davidsinclair Reel by @fixbrainfog - Dr. David Sinclair is a Harvard professor of genetics and one of the world's leading longevity researchers. This is what he takes every day to slow hi
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@fixbrainfog
Dr. David Sinclair is a Harvard professor of genetics and one of the world's leading longevity researchers. This is what he takes every day to slow his biological aging — and why. NMN — 1 gram every morning. Boosts NAD+ levels which decline with age and are critical for cellular energy and DNA repair. Resveratrol — 1 gram taken with fat to maximise absorption. Activates sirtuins — the longevity genes that regulate aging. Spermidine — 1 to 2mg daily. Triggers autophagy — your body's cellular cleaning process that removes damaged cells. Glycine — supports collagen production and is a precursor to glutathione — your body's master antioxidant. Metformin — switched to berberine as a natural alternative for blood sugar regulation and metabolic health. Vitamin D3 and K2 — essential for immune function, bone density, cardiovascular health and hormonal regulation. Baby aspirin — for cardiovascular protection. Taken with a small amount of fat. CoQ10 — to offset the depletion caused by his statin use and support mitochondrial function. Sinclair also skips breakfast, exercises regularly and monitors his biological age — not his chronological age. Save this. Follow @fixbrainfog — Human trials has started this year for age reversal studies and we have a post on it today. . ⚠️ Educational only. Not medical advice. Never begin a supplement protocol without consulting a qualified healthcare professional. Individual needs vary significantly. 🎙️ Source: Dr. David Sinclair — Professor of Genetics, Harvard Medical School, Author of Lifespan Diary of a CEO with Steven Bartlett @davidsinclairphd @thediaryofaceopodcast #DavidSinclair #Longevity #FixBrainFog #NMN #Resveratrol #DiaryOfACEO #Supplements #AntiAging #Lifespan #BrainHealth #HealthOptimisation #Harvard #Spermidine #NAD #Biohacking
#Davidsinclair Reel by @cyfrowa_inteligencja_pl (verified account) - David Sinclair to genetyk z Harvard Medical School, od lat kojarzony z badaniami nad starzeniem i częściowym przeprogramowaniem komórek. W tym roku je
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@cyfrowa_inteligencja_pl
David Sinclair to genetyk z Harvard Medical School, od lat kojarzony z badaniami nad starzeniem i częściowym przeprogramowaniem komórek. W tym roku jego podejście weszło na etap badań klinicznych u ludzi, bo FDA dopuściła start badania fazy 1 terapii ER 100 w chorobach nerwu wzrokowego. Sinclair mówi, że udało się „cofnąć wiek” złożonej tkanki u myszy: wzięto stare, oślepłe myszy, przeprogramowano komórki oka i według niego biologiczny wiek oka spadł o około 80%, a zwierzęta odzyskały widzenie. Potem rozwija tezę, że ciało wciąż ma informację o młodości, tylko z wiekiem przestaje z niej korzystać, a odpowiedni „reset” potrafi ją znowu uruchomić. Podkreśla też, że to nie musi dotyczyć tylko oka, bo mechanizm wygląda na bardziej uniwersalny, wspomina o skórze i mięśniach. Na koniec zaznacza, że bezpieczeństwo jest kluczowe: trwają testy na naczelnych, a ambicją jest dojście do terapii przywracających wzrok u ludzi, przy czym najbliższe badania kliniczne są przede wszystkim po to, by sprawdzić, czy to jest bezpieczne. #medycyna #zdrowie #młodość #starość #życie
#Davidsinclair Reel by @goscarvb - Prof. David Sinclair dalam penelitiannya telah berhasil memulihkan penglihatan pada tikus. Terobosan ini kini sedang dipersiapkan untuk uji klinis pad
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@goscarvb
Prof. David Sinclair dalam penelitiannya telah berhasil memulihkan penglihatan pada tikus. Terobosan ini kini sedang dipersiapkan untuk uji klinis pada manusia. Berikut adalah poin-poin utamanya: 👁Pemulihan pada Hewan: Pada tahun 2020, lab Sinclair di Harvard Medical School menerbitkan studi di jurnal Nature yang menunjukkan bahwa terapi gen menggunakan faktor pemrograman ulang seluler (gen OSK) dapat membalikkan hilangnya penglihatan akibat usia dan kerusakan saraf optik (glaukoma) pada tikus. 👁Uji Klinis Manusia: Perusahaan yang didirikan Sinclair, Life Biosciences, telah menerima lampu hijau dari FDA pada awal 2026 untuk memulai uji klinis Fase 1 pada manusia. Uji coba ini akan fokus pada pasien dengan glaukoma dan neuropati optik iskemik anterior non-arteritik (NAION). 👁Teori Informasi Penuaan: Sinclair berpendapat bahwa penuaan disebabkan oleh hilangnya informasi epigenetik (seperti goresan pada CD). Dengan teknologi ini, sel "diprogram ulang" untuk kembali ke kondisi yang lebih muda dan fungsional. 👁Target Masa Depan: Jika berhasil pada mata, Sinclair optimis teknologi ini dapat diterapkan pada jaringan tubuh lainnya untuk mengobati berbagai penyakit terkait usia.
#Davidsinclair Reel by @thelongevitychronicle - Follow @thelongevitychronicle for science - backed longevity tips. Modern life has quietly removed many of the challenges our biology evolved to hand
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@thelongevitychronicle
Follow @thelongevitychronicle for science - backed longevity tips. Modern life has quietly removed many of the challenges our biology evolved to handle. For most of human history, people experienced regular stressors like cold, hunger, and physical exertion. Today, we sit more, move less, and have constant access to food. According to aging researcher David Sinclair, this shift may be suppressing powerful survival pathways inside our cells. This concept is called hormesis. In simple terms, small amounts of stress activate protective mechanisms that help the body repair damage, reduce inflammation, and maintain cellular health. Activities like exercise, fasting, and exposure to mild environmental stress can trigger these ancient biological systems. Scientists believe these responses evolved billions of years ago to help organisms survive difficult conditions. When activated, they may help protect against disease and slow aspects of biological aging. The idea is simple but powerful: a little controlled stress can make the body stronger and more resilient over time. Credits: Video: @drchatterjee Speaker: @davidsinclairphd. Harvard Professor studying aging. Disclaimer: We are not offering health advice on this page. Content is for informational purposes only. Please consult with a medical professional before applying any material contained. Follow @thelongevitychronicle for science - backed longevity tips. #longevity #health #hormesis #fasting #healthspan
#Davidsinclair Reel by @longevity_enthusiasts - Major breakthrough by David Sinclair PhD #health #healthyliving #longevity #davidsinclair #vitality #breakthrough #healthspan #lifespan #livelonger #a
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@longevity_enthusiasts
Major breakthrough by David Sinclair PhD #health #healthyliving #longevity #davidsinclair #vitality #breakthrough #healthspan #lifespan #livelonger #agewell #antiaging
#Davidsinclair Reel by @longevity2.0 - Comment NEWS to join my Longevity Newsletter and get the latest longevity research and practical tips to live healthier and age better. This might be
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@longevity2.0
Comment NEWS to join my Longevity Newsletter and get the latest longevity research and practical tips to live healthier and age better. This might be the most important shift in modern medicine: What if we’ve been targeting the wrong thing all along? According to David Sinclair, many of the diseases we treat separately today may share a common root: Aging itself. Think about it: • Alzheimer’s • Cancer • Heart disease • Metabolic disorders They look different… but they often rise together with age. In lab models, when scientists reverse aspects of biological aging, something remarkable happens: The disease doesn’t just improve. Sometimes, it disappears. Why? Because a younger biological state means: • Better DNA repair • Stronger cellular function • Improved resilience to damage • More efficient tissue regeneration In other words, the body regains its ability to heal itself. Important context: Most of this research is still in animal models, and we are not yet able to fully reverse aging in humans. But the implication is massive: Instead of treating diseases one by one… we may be able to target the underlying process that drives them all. That process is aging. And if we can slow it — or even partially reverse it — we may change the trajectory of multiple diseases at once. That’s the real promise of longevity science. — Copyright disclosure: Educational commentary on publicly available material featuring David Sinclair. All rights belong to their respective copyright owners. Content shared for informational and educational purposes only.
#Davidsinclair Reel by @mirela.suta - Num vídeo do investigador de Harvard David Sinclair, um dos grandes nomes da ciência da longevidade, ele explica que o envelhecimento pode ser visto c
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@mirela.suta
Num vídeo do investigador de Harvard David Sinclair, um dos grandes nomes da ciência da longevidade, ele explica que o envelhecimento pode ser visto como uma condição biológica — e que o nosso corpo pode, em certa medida, ser “reprogramado”. Grande parte destas investigações envolve proteínas chamadas Sirtuins, especialmente a SIRT1, muitas vezes conhecidas como “proteínas da longevidade”. Estas proteínas ajudam a: �• reparar o ADN �• proteger as células �• reduzir processos inflamatórios �• e abrandar alguns mecanismos associados ao envelhecimento celular. E aqui surge algo muito interessante… Na indústria cosmética já existem ingredientes estudados por estimular ou apoiar estas vias celulares associadas às sirtuínas na pele. Entre alguns dos ativos mais conhecidos encontram-se: ✨ Resveratrol – poderoso antioxidante derivado da uva, estudado pela sua capacidade de ativar a SIRT1 e proteger a pele do envelhecimento celular. ✨ Extrato de semente de uva e polifenóis – ricos em compostos antioxidantes que ajudam a estimular os mecanismos naturais de defesa celular. ✨ Niacinamida (vitamina B3) – contribui para aumentar os níveis de NAD+, uma molécula essencial para a atividade das sirtuínas. ✨ Quercetina – flavonoide antioxi dante presente em vários extratos botânicos e associado à ativação de vias de longevidade celular. ✨ Fisetina – composto antioxidante estudado pelos seus potenciais efeitos na proteção celular. ✨ Biopeptídeos de levedura (Kluyveromyces) – demonstraram aumentar a expressão da SIRT1 em células da pele e ajudar a reduzir sinais de fotoenvelhecimento. ✨ Peptídeos de cobre (GHK-Cu) – associados à regeneração da pele e aos processos de reparação celular. Ou seja, a chamada “longevity skincare” já começa a trazer para a cosmética conceitos inspirados na ciência da longevidade e na biologia do envelhecimento. 💡 Alguns outros ingredientes que também aparecem em investigação ligada a sirtuínas na pele: * Pterostilbene (parente do resveratrol) * Curcumina * EGCG do chá verde * Ácido ferúlico #LongevidadeCelular #BiologiaDoEnvelhecimento #LongevitySkincare #Sirtuins #SkinLongevity AgeingScience

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