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PUAsthma is a chronic inflammatory disorder of the airways characterized by variable and recurring symptoms, including wheezing, shortness of breath, chest tightness, and coughing. It affects people of all ages and is often triggered by environmental factors or genetic predispositions.
1. Core Pathophysiology
Airway Inflammation: Involves the infiltration of various inflammatory cells, particularly eosinophils, mast cells, and T-lymphocytes.
Bronchoconstriction: Acute narrowing of the airways caused by the contraction of bronchial smooth muscle in response to triggers.
Bronchoconstriction: Acute narrowing of the airways caused by the contraction of bronchial smooth muscle in response to triggers.
Airway Hyperresponsiveness: An exaggerated bronchoconstrictor response to various stimuli, such as cold air or allergens.
Airway Remodeling: Structural changes over time, including basement membrane thickening and smooth muscle hypertrophy, which can lead to irreversible airflow limitation
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