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A tweaker is an individual experiencing the intense, often erratic effects of prolonged methamphetamine use, specifically during a phase of extreme sleep deprivation. In this state, the brain’s dopamine levels are depleted, replacing the initial euphoria with high-strung anxiety, paranoia, and a physical inability to remain still. This often manifests as "punning"—the compulsive performance of repetitive, aimless tasks—and can lead to unpredictable behavior or stimulant-induced psychosis as the body and mind reach a point of total exhaustion.
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