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We review how ammonium trichloroacetate stimulates keratinocytes in the epidermis,
triggering the release of key cytokines and growth factors such as PDGF, TGF-α, TGF-β, and VEGF.
These signals travel to the dermis, activating fibroblasts to promote collagen I, collagen III,
and hyaluronic acid production within the extracellular matrix.
We also discuss the role of homocysteic acid, its interaction with melanocyte NMDA receptors,
and how this pathway supports melanosome transfer and pigment clearance through natural epidermal turnover.
Understanding the “why” behind a treatment — at the cellular level — is essential for informed clinical decision-making.
Comment 👍🏼 below if you agree that understanding cellular mechanism of action helps determine the optimum treatment plan for the patient.
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#MechanismOfAction #AestheticMedicine
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