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WO🧬 How your cells fix broken DNA — single vs double-strand damage 👇
Every day, your DNA takes hits from radiation, chemicals, and normal metabolism.
Luckily, your cells have repair crews on standby 🔧
🔹 Single-strand breaks (SSBs)
When only ONE side of the DNA helix breaks:
➡️ PARP (Poly ADP-ribose polymerase) jumps in first
➡️ It detects the break, recruits repair proteins
➡️ The gap is filled + ligated back together
PARP = your cell’s “first responder” 🚑
🔹 Double-strand breaks (DSBs)
These are WAY more dangerous — both DNA strands snap 💥
Your cell has two major options:
1️⃣ Non-homologous end joining (NHEJ)
Quick fix, but error-prone
➡️ Ends are stitched together even if bases don’t match perfectly
2️⃣ Homologous recombination (HR)
High-fidelity repair
➡️ Uses the sister chromatid as a template
➡️ BRCA1 plays a crucial role in coordinating and stabilizing this process
BRCA1 = the architect of accurate DNA repair 🧠
When BRCA1 doesn’t work properly, cells rely on PARP instead —
and THIS is why PARP inhibitors are used in BRCA-mutated cancers 💊
They block the “backup system,” causing cancer cells to collapse under DNA damage.
Your cells repair DNA every second —
a microscopic maintenance system keeping you alive 🔬✨
#DNARepair #BRCA1 #PARP #Genetics #MolecularBiology #CancerBiology #MedicalEducation #MedSchool #MedEd #MedicineReels #HomologousRecombination #NHEJ
Don’t forget to hit that follow button 👆
@wowmedicine
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[PŁATNA WSPÓŁPRACA Z PARP]
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🔬 Lab](https://image.pictame.com/img/536627613_18519623719022366_5097855513649624094_n.jpg?hash=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)
